Vivo Recording and Optogenetics

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Academic Research Interconnect Case Study

UC San Diego Lim Lab Sensor Board Interconnect for Compact, High Flex Applications

A UC San Diego neurobiology research team in the Lim Lab develops tools and experiments to study basal ganglia circuitry and behavior using approaches such as in vivo recording and optogenetics in mice.
To support a custom research instrument, the team needed a reliable interconnect to link a main electronics board to a sensor board in a tight mechanical envelope.

The challenge

The research team contacted PICA looking for an interconnect solution that could handle three competing requirements:

Slim, low profile packaging to fit within a compact assembly
High density routing in a narrow flex width
Continuous flexing during operation, requiring long term mechanical reliability

Off the shelf cabling and rigid interconnect options risked adding bulk, limiting routing density, or failing under repeated bending.

PICA’s engineering approach

PICA reviewed the application details and identified flexibility and mechanical endurance as primary drivers, alongside routing density and overall profile. The solution required material and process choices designed to preserve flex performance while meeting electrical and assembly needs.

The solution

PICA delivered a double sided flexible printed circuit that accommodated the full routing set while maintaining a narrow width and low profile.

Key design and fabrication elements included:

Double sided flexible printed circuit to support high density routing in a slim form factor
Rolled annealed copper on an adhesiveless base laminate to improve bend performance during continuous flexing
Button plating selected to help preserve flexibility while meeting interconnect requirements
Turnkey build support including design, flex fabrication, and assembly of the two board connectors

What PICA delivered

Engineering review and design support based on the application constraints
Fabricated flexible printed circuits built for repeated bend use
Assembled connector interfaces for main board and sensor board integration
A turnkey interconnect solution to reduce lab integration time and simplify procurement

Outcome and impact

With a purpose built flex interconnect, the research team received a compact, high density, low profile link between boards that was designed specifically for continuous bending during operation. This supported faster integration into their research hardware and improved confidence in mechanical reliability for ongoing experimentation.

Why it matters for academic programs

Academic research hardware often combines tight mechanical packaging, custom sensing, and frequent handling or motion. The Lim Lab’s work focuses on understanding neural circuits and behavior in animal models, which commonly depends on compact instrumentation and dependable signal pathways.
PICA helps bridge the gap between lab prototypes and buildable, repeatable interconnect solutions through practical engineering support and turnkey execution.

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Vivo Recording and Optogenetics